Opportunity Information: Apply for RFA AG 18 013
The funding opportunity titled "Continuation of the AMP-AD Target Discovery and Preclinical Validation Consortium (U01 Clinical Trial Optional)" (RFA-AG-18-013) is a National Institutes of Health (NIH) cooperative agreement intended to keep building and enlarging the Accelerating Medicines Partnership - Alzheimer’s Disease (AMP-AD) effort. The core aim is to strengthen an open-science, systems-biology program that uses large-scale biological data and computational methods to uncover new therapeutic targets and biomarkers for Alzheimer’s disease (AD) and AD-related dementias. Rather than focusing on a single gene or pathway at a time, the program emphasizes data-driven discovery, where multiple layers of molecular and clinical information are integrated to better explain how brain health shifts into disease and to identify points where an intervention could realistically change that trajectory.
A central feature of this announcement is the push to develop predictive network models of brain health and disease. In practice, that means using systems biology approaches to map and analyze complex biological networks (for example, gene regulation networks, protein interaction networks, pathway-level networks, and multi-omic relationships) and then using those models to predict which genes, proteins, cell types, or pathways are most likely to be causal drivers or strong modifiers of disease. The goal is not only to generate hypotheses, but also to prioritize targets in a rational way and connect them to measurable biomarkers that could help track disease progression, stratify patients, or monitor response to treatment. The "preclinical validation" component signals that targets emerging from these models are expected to be tested in experimental systems to build confidence that they are truly relevant and actionable before moving toward clinical development.
This opportunity uses a U01 mechanism, which is a cooperative agreement. That matters because a cooperative agreement typically involves substantial scientific and programmatic involvement from the NIH compared to a standard investigator-initiated grant. The intent is to operate as a consortium with coordinated milestones, shared standards, and active collaboration across participating teams. The open-science aspect is also a defining requirement in spirit: consortium work is expected to contribute broadly usable datasets, analytic outputs, and target/biomarker findings to the research community, accelerating progress beyond the walls of any single institution. In the AMP model, rapid data sharing, harmonized methods, and collaborative governance are usually treated as essential for speed and reproducibility, especially in a field as complex and historically difficult as AD drug discovery.
The activity category is health, and the administering agency is the U.S. Department of Health and Human Services through NIH, with the CFDA number listed as 93.866. The announcement was created on September 27, 2017, with an original closing date of February 20, 2018. The expected number of awards is six, and the award ceiling is $1,000,000, indicating that each project is expected to be substantial but still bounded, likely with an emphasis on defined deliverables that fit within consortium priorities and timelines.
Eligibility is broad and includes many types of organizations, reflecting the consortium nature of the work and the mix of expertise needed for systems biology and translational neuroscience. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized) and other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other entities as allowed under the additional eligibility information. This wide net is consistent with the reality that meaningful target discovery and preclinical validation often require cross-sector collaboration among academic groups, computational biology teams, biotech and pharma partners, and organizations capable of generating or analyzing high-dimensional data at scale.
The "Clinical Trial Optional" label indicates that applicants may propose clinical trial components if they are appropriate, but a clinical trial is not mandatory for the overall purpose of the announcement. Given the stated emphasis on target discovery, network modeling, and preclinical validation, many responsive applications would likely focus primarily on computational modeling, multi-omic integration, mechanistic studies in model systems, and biomarker development or validation in existing cohorts, with optional clinical elements where they directly support target/biomarker validation.
Overall, this grant opportunity is designed to move the AD field toward a more predictive, data-integrated model of disease biology, where targets and biomarkers are not chosen simply because they are associated with pathology, but because they emerge from coherent network-based evidence and can be validated experimentally. By continuing and expanding the AMP-AD consortium under an open-science framework, the program aims to shorten the path from big data to credible drug targets, improve reproducibility, and create shared resources that help the entire research community push toward more effective therapies for Alzheimer’s disease and related dementias.Apply for RFA AG 18 013
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Continuation of the AMP-AD Target Discovery and Preclinical Validation Consortium (U01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on Sep 27, 2017.
- Applicants must submit their applications by Feb 20, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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